Symbol: |
Hck |
Name: |
hemopoietic cell kinase |
Description: |
ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog);
INVOLVED IN defense response to Gram-positive bacterium (ortholog); negative
regulation of apoptotic process (ortholog); peptidyl-tyrosine phosphorylation
(ortholog); PARTICIPATES IN Interleukin-6 signaling pathway; eicosanoids
signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; FOUND
IN actin filament (ortholog); caveola (ortholog); extrinsic to internal side of
plasma membrane (ortholog); INTERACTS WITH 2,6-di-tert-butyl-4-methylphenol;
ammonium chloride; cefaloridine |
Type: |
protein-coding |
RefSeq Status: |
VALIDATED
|
Also known as: |
HCTK; hemopoietic cell tyrosine kinase; Hctk; hemopoietic cell kinase;
p56-HCK; tyrosine-protein kinase HCK; p56Hck; p59Hck; hematopoietic cell kinase
|
Orthologs: |
Homo sapiens
: HCK (hemopoietic cell kinase) Mus
musculus : Hck (hemopoietic cell
kinase) |
Latest Assembly: |
RGSC Genome Assembly v3.4 |
Position: |
Map |
Chr |
Position |
Strand |
Source |
Rat Cytogenetic Map |
3 |
q41 |
|
NCBI |
Rat Rnor_5.0 |
3 |
154,982,909 - 155,025,529 |
+ |
NCBI |
RGSC Genome Assembly v3.4 |
3 |
143,447,697 - 143,490,281 |
+ |
NCBI |
Rat Celera Assembly |
3 |
140,318,662 - 140,361,702 |
+ |
NCBI |
Genome Assembly 3.1 |
3 |
143,353,318 - 143,395,900 |
+ |
NCBI |
RH 3.4 |
3 |
1263.9 |
|
RGD |
|
Model |
|
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Biological
Process
Cellular
Component
Molecular
Function
Molecular Pathway Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Biological
Process
|
|
positive
regulation of cell proliferation (IEA,ISO,ISS) |
|
protein
autophosphorylation (IEA,ISO,ISS) |
|
regulation
of cell shape (IEA,ISO,ISS) |
|
regulation
of phagocytosis (IEA,ISO,ISS) |
|
regulation
of podosome assembly (IEA,ISO,ISS) |
|
regulation
of sequence-specific DNA binding transcription factor activity (IEA,ISO) |
|
Cellular
Component
Molecular
Function
Molecular Pathway Annotations
References - curated
1. |
Bonaldo MF, etal.,
Genome Res 1996 Sep;6(9):791-806. |
2. |
GOA data from the GO
Consortium |
3. |
Kwitek AE, etal.,
Genome Res. 2004 Apr;14(4):750-7 |
4. |
Lock P, etal., Mol
Cell Biol 1991 Sep;11(9):4363-70. |
5. |
MGD data from the GO
Consortium |
6. |
NCBI rat LocusLink
and RefSeq merged data July 26, 2002 |
7. |
Okano Y, etal.,
Biochem Biophys Res Commun 1991 Dec 31;181(3):1137-44. |
8. |
Pipeline to import
Pathway Interaction Database annotations from NCI into RGD |
9. |
RGD automated import
pipeline for gene-chemical interactions |
10. |
Strausberg RL, etal.,
Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec
11. |
11. |
Tentative Sequence
Data IDs. TIGR Gene Index, Rat Data |
References - uncurated
RGD Disease Portals
Hck has been annotated
in the following RGD Disease Portals.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Genomics
Comparative Map Data
Hck (Rattus norvegicus) |
Map |
Chr |
Position |
Strand |
Source |
Rat Cytogenetic Map |
3 |
q41 |
|
NCBI |
Rat Rnor_5.0 |
3 |
154,982,909 - 155,025,529 |
+ |
NCBI |
RGSC Genome Assembly v3.4 |
3 |
143,447,697 - 143,490,281 |
+ |
NCBI |
Rat Celera Assembly |
3 |
140,318,662 - 140,361,702 |
+ |
NCBI |
Genome Assembly 3.1 |
3 |
143,353,318 - 143,395,900 |
+ |
NCBI |
RH 3.4 |
3 |
1263.9 |
|
RGD |
|
HCK (Homo sapiens) |
Map |
Chr |
Position |
Strand |
Source |
Human Genome Assembly HuRef |
20 |
27,428,653 - 27,478,333 |
+ |
NCBI |
Human Genome Assembly GRCh37 |
20 |
30,639,991 - 30,689,659 |
+ |
NCBI |
Human Genome Assembly Build 36 |
20 |
30,103,718 - 30,153,320 |
+ |
NCBI |
Human Cytogenetic Map |
20 |
q11-q12 |
|
NCBI |
Human Genome Assembly |
20 |
30,103,717 - 30,153,316 |
|
NCBI |
|
Hck (Mus musculus) |
Map |
Chr |
Position |
Strand |
Source |
Mouse Genome Assembly GRCm38 |
2 |
153,108,468 - 153,151,441 |
+ |
NCBI |
Mouse cM Map |
2 |
86.0 |
|
NCBI |
Mouse Celera Assembly |
2 |
158,934,831 - 158,977,872 |
+ |
NCBI |
Mouse Genome Assembly Build 37 |
2 |
152,934,204 - 152,977,177 |
+ |
NCBI |
Mouse Genome Assembly Build 36.1 |
2 |
152,934,244 - 152,977,172 |
+ |
NCBI |
Mouse Cytogenetic Map |
2 |
H1 |
|
NCBI |
|
Position Markers
J03023 |
Map |
Chr |
Position |
Strand |
Source |
RGSC Genome Assembly v3.4 |
3 |
143,490,054 - 143,490,208 |
|
UniSTS |
Rat Celera Assembly |
3 |
140,361,475 - 140,361,629 |
|
UniSTS |
|
RH94532 |
Map |
Chr |
Position |
Strand |
Source |
RGSC Genome Assembly v3.4 |
3 |
143,490,039 - 143,490,208 |
|
UniSTS |
Rat Celera Assembly |
3 |
140,361,460 - 140,361,629 |
|
UniSTS |
RH 3.4 |
3 |
1263.9 |
|
UniSTS |
|
RH137385 |
Map |
Chr |
Position |
Strand |
Source |
RGSC Genome Assembly v3.4 |
3 |
143,490,089 - 143,490,244 |
|
UniSTS |
Rat Celera Assembly |
3 |
140,361,510 - 140,361,665 |
|
UniSTS |
RH 3.4 |
3 |
1275.0 |
|
UniSTS |
|
UniSTS:498385
|
Map |
Chr |
Position |
Strand |
Source |
RGSC Genome Assembly v3.4 |
3 |
143,489,822 - 143,490,224 |
|
UniSTS |
Rat Celera Assembly |
3 |
140,361,243 - 140,361,645 |
|
UniSTS |
|
QTLs in Region (RGSC Genome Assembly
v3.4)
619618 |
Rf3 |
Renal disease susceptibility QTL 3 |
6.5 |
.001 |
Renal function |
urine albumin level |
3 |
108688653 |
153688653 |
Rat |
631541 |
Bp81 |
Blood pressure QTL 81 |
4 |
|
Blood pressure |
systolic |
3 |
124893448 |
171063335 |
Rat |
631841 |
Niddm39 |
Non-insulin dependent diabetes mellitus QTL 39 |
3.36 |
|
Glucose level |
post-pancreatectomy |
3 |
93894678 |
161985069 |
Rat |
631665 |
Bw8 |
Body weight QTL 8 |
5.5 |
|
Body weight |
|
3 |
47722501 |
171063335 |
Rat |
631673 |
Iddm13 |
Insulin dependent diabetes mellitus QTL 13 |
1.1 |
.014 |
Insulin level |
|
3 |
131188558 |
163778754 |
Rat |
1559282 |
Emca5 |
Estrogen-induced mammary cancer QTL 5 |
3.9 |
|
Mammary tumor susceptibility |
estradiol-induced |
3 |
41054012 |
171063335 |
Rat |
1300159 |
Kidm4 |
Kidney mass QTL 4 |
3.83 |
|
Kidney mass |
hypertension related |
3 |
121618954 |
159769019 |
Rat |
1300161 |
Rf10 |
Renal function QTL 10 |
3.57 |
|
Renal function |
hypertension related renal vascular resistance |
3 |
101298208 |
163335184 |
Rat |
1300173 |
Rf11 |
Renal function QTL 11 |
3.38 |
|
Renal function |
hypertension related renal blood flow |
3 |
121618954 |
147990731 |
Rat |
1576306 |
Schws3 |
Schwannoma susceptibility QTL 3 |
|
.001 |
Neural tumor susceptibility |
tumor incidence |
3 |
120714678 |
165714678 |
Rat |
1581568 |
Rf53 |
Renal function QTL 53 |
|
|
Renal function |
urine protein level |
3 |
53876762 |
163443738 |
Rat |
1578653 |
Vnigr3 |
Vascular neointimal growth QTL 3 |
3.1 |
|
Vascular neointimal growth after injury |
blood vessel neointimal area |
3 |
132947812 |
171063335 |
Rat |
1578656 |
Vnigr2 |
Vascular neointimal growth QTL 2 |
4.2 |
|
Vascular neointimal growth after injury |
blood vessel lumen size |
3 |
132947812 |
171063335 |
Rat |
1578754 |
Stresp16 |
Stress response QTL 16 |
4 |
.001 |
Stress response |
plasma renin activity |
3 |
113902006 |
158902006 |
Rat |
1581546 |
Pur13 |
Proteinuria QTL 13 |
2.93 |
.0335 |
Renal function |
urine protein level |
3 |
76620970 |
148642985 |
Rat |
2301970 |
Bw81 |
Body weight QTL 81 |
5.19 |
|
Body weight |
|
3 |
39052756 |
158038027 |
Rat |
2292591 |
Esta4 |
Estrogen-induced thymic atrophy QTL 4 |
|
|
Gland mass |
thymus |
3 |
44551252 |
149496698 |
Rat |
2293087 |
Iddm27 |
Insulin dependent diabetes mellitus QTL 27 |
2.37 |
|
Glucose level |
insulin-dependent |
3 |
96506745 |
149496698 |
Rat |
1598877 |
Bp285 |
Blood pressure QTL 285 |
1.5 |
.03 |
Blood pressure |
systolic |
3 |
122541511 |
167541511 |
Rat |
2312670 |
Bw94 |
Body weight QTL 94 |
|
.01 |
Body weight |
adiposity index |
3 |
97523869 |
170016653 |
Rat |
2312673 |
Scl63 |
Serum cholesterol level QTL 63 |
|
.001 |
Lipid level |
serum cholesterol |
3 |
97523869 |
170016653 |
Rat |
2312659 |
Slep7 |
Serum leptin concentration QTL 7 |
|
.001 |
Hormone level |
leptin |
3 |
97523869 |
170016653 |
Rat |
2302373 |
Gluco39 |
Glucose level QTL 39 |
5.01 |
|
Glucose level |
|
3 |
97524000 |
163778606 |
Rat |
2303620 |
Vencon4 |
Ventilatory control QTL 4 |
3.1 |
|
Ventilatory control |
hypoxic challenge |
3 |
127988419 |
170016653 |
Rat |
2298477 |
Eau4 |
Experimental allergic uveoretinitis QTL 4 |
|
.0011 |
Uvea inflammation |
|
3 |
139485124 |
171063335 |
Rat |
2301971 |
Cm71 |
Cardiac mass QTL 71 |
4.63 |
|
Cardiac mass |
left ventricle |
3 |
39052756 |
158038027 |
Rat |
5686842 |
Rf59 |
Renal function QTL 59 |
|
|
Renal function |
urine protein level |
3 |
141890119 |
149038578 |
Rat |
Sequence
Nucleotide Sequences
Reference Sequences
RefSeq Acc Id: |
NM_013185 |
RefSeq Status: |
VALIDATED |
Type: |
CODING |
Protein Acc Id: |
NP_037317 |
Position: |
Map |
Chr |
Position |
Strand |
Source |
Rat Rnor_5.0 |
3 |
154,982,909 - 155,025,529 |
+ |
NCBI |
RGSC Genome Assembly v3.4 |
3 |
143,447,697 - 143,490,281 |
+ |
RGD |
Rat Celera Assembly |
3 |
140,318,662 - 140,361,702 |
+ |
NCBI |
|
Protein Sequences
Strain Variation
FHH Sequence Variants
1: |
143490036 |
143490037 |
3 |
A |
C |
16 |
56 |
homozygous |
2: |
143488515 |
143488516 |
3 |
T |
A |
15 |
46 |
homozygous |
3: |
143488485 |
143488486 |
3 |
C |
G |
16 |
53 |
homozygous |
4: |
143486820 |
143486821 |
3 |
A |
T |
13 |
37 |
homozygous |
5: |
143486076 |
143486077 |
3 |
A |
G |
9 |
30 |
homozygous |
6: |
143486033 |
143486034 |
3 |
G |
A |
13 |
44 |
homozygous |
7: |
143485800 |
143485801 |
3 |
G |
A |
25 |
76 |
homozygous |
8: |
143484866 |
143484867 |
3 |
C |
T |
13 |
45 |
homozygous |
9: |
143484724 |
143484725 |
3 |
C |
A |
18 |
62 |
homozygous |
10: |
143484513 |
143484514 |
3 |
A |
G |
22 |
76 |
homozygous |
11: |
143484445 |
143484446 |
3 |
A |
C |
7 |
7 |
heterozygous |
12: |
143484444 |
143484445 |
3 |
C |
A |
6 |
16 |
homozygous |
13: |
143484142 |
143484143 |
3 |
T |
C |
19 |
61 |
homozygous |
14: |
143483875 |
143483876 |
3 |
G |
A |
17 |
54 |
homozygous |
15: |
143483696 |
143483697 |
3 |
C |
G |
11 |
38 |
homozygous |
16: |
143482996 |
143482997 |
3 |
C |
T |
19 |
58 |
possibly homozygous |
17: |
143482857 |
143482858 |
3 |
C |
T |
21 |
67 |
homozygous |
18: |
143482756 |
143482757 |
3 |
G |
A |
20 |
60 |
homozygous |
19: |
143482681 |
143482682 |
3 |
G |
A |
16 |
56 |
homozygous |
20: |
143482495 |
143482496 |
3 |
A |
G |
29 |
85 |
homozygous |
21: |
143482330 |
143482331 |
3 |
C |
G |
25 |
84 |
homozygous |
22: |
143482235 |
143482236 |
3 |
T |
C |
26 |
83 |
homozygous |
23: |
143481463 |
143481464 |
3 |
A |
G |
7 |
23 |
homozygous |
24: |
143481286 |
143481287 |
3 |
G |
A |
11 |
33 |
possibly homozygous |
25: |
143481255 |
143481256 |
3 |
C |
G |
15 |
45 |
homozygous |
26: |
143481095 |
143481096 |
3 |
C |
T |
14 |
47 |
homozygous |
27: |
143480633 |
143480634 |
3 |
G |
C |
22 |
61 |
homozygous |
28: |
143480301 |
143480302 |
3 |
G |
A |
17 |
54 |
homozygous |
29: |
143479842 |
143479843 |
3 |
G |
A |
15 |
44 |
homozygous |
30: |
143479493 |
143479494 |
3 |
A |
G |
16 |
50 |
homozygous |
31: |
143477980 |
143477981 |
3 |
C |
T |
23 |
71 |
homozygous |
32: |
143477252 |
143477253 |
3 |
G |
A |
11 |
37 |
homozygous |
33: |
143476325 |
143476326 |
3 |
G |
A |
20 |
67 |
homozygous |
34: |
143476204 |
143476205 |
3 |
T |
A |
15 |
40 |
homozygous |
35: |
143475846 |
143475847 |
3 |
G |
A |
17 |
57 |
homozygous |
36: |
143474904 |
143474905 |
3 |
A |
G |
16 |
53 |
homozygous |
37: |
143474359 |
143474360 |
3 |
G |
A |
21 |
66 |
homozygous |
38: |
143474100 |
143474101 |
3 |
T |
C |
21 |
63 |
homozygous |
39: |
143473396 |
143473397 |
3 |
T |
C |
7 |
20 |
possibly homozygous |
40: |
143473068 |
143473069 |
3 |
A |
G |
8 |
25 |
homozygous |
41: |
143472976 |
143472977 |
3 |
C |
T |
13 |
39 |
homozygous |
42: |
143471575 |
143471576 |
3 |
G |
T |
21 |
74 |
homozygous |
43: |
143471188 |
143471189 |
3 |
G |
T |
16 |
51 |
homozygous |
44: |
143470845 |
143470846 |
3 |
A |
T |
14 |
44 |
homozygous |
45: |
143470349 |
143470350 |
3 |
G |
A |
13 |
35 |
possibly homozygous |
46: |
143469952 |
143469953 |
3 |
A |
G |
25 |
74 |
homozygous |
47: |
143469877 |
143469878 |
3 |
G |
A |
13 |
42 |
possibly homozygous |
48: |
143469248 |
143469249 |
3 |
T |
C |
19 |
62 |
homozygous |
49: |
143468807 |
143468808 |
3 |
C |
A |
13 |
45 |
homozygous |
50: |
143467598 |
143467599 |
3 |
G |
A |
25 |
70 |
possibly homozygous |
51: |
143467505 |
143467506 |
3 |
C |
T |
29 |
99 |
homozygous |
52: |
143466167 |
143466168 |
3 |
A |
G |
14 |
44 |
homozygous |
53: |
143465693 |
143465694 |
3 |
A |
G |
7 |
16 |
homozygous |
54: |
143465329 |
143465330 |
3 |
C |
A |
7 |
7 |
heterozygous |
55: |
143464979 |
143464980 |
3 |
A |
G |
11 |
28 |
possibly homozygous |
56: |
143464865 |
143464866 |
3 |
C |
A |
18 |
60 |
homozygous |
57: |
143462641 |
143462642 |
3 |
G |
A |
23 |
71 |
homozygous |
58: |
143462140 |
143462141 |
3 |
A |
G |
13 |
35 |
homozygous |
59: |
143461979 |
143461980 |
3 |
C |
T |
19 |
60 |
homozygous |
60: |
143459264 |
143459265 |
3 |
G |
A |
3 |
11 |
homozygous |
61: |
143459236 |
143459237 |
3 |
T |
C |
4 |
12 |
homozygous |
62: |
143459010 |
143459011 |
3 |
C |
T |
7 |
18 |
homozygous |
63: |
143458713 |
143458714 |
3 |
C |
T |
17 |
55 |
homozygous |
64: |
143458064 |
143458065 |
3 |
G |
A |
15 |
51 |
homozygous |
65: |
143457562 |
143457563 |
3 |
C |
G |
6 |
20 |
homozygous |
66: |
143455794 |
143455795 |
3 |
C |
T |
15 |
48 |
homozygous |
67: |
143455790 |
143455791 |
3 |
A |
G |
16 |
55 |
homozygous |
68: |
143455219 |
143455220 |
3 |
C |
T |
12 |
35 |
homozygous |
69: |
143453942 |
143453943 |
3 |
G |
A |
26 |
84 |
homozygous |
70: |
143452777 |
143452778 |
3 |
G |
A |
16 |
51 |
homozygous |
71: |
143452509 |
143452510 |
3 |
C |
T |
19 |
60 |
homozygous |
72: |
143452300 |
143452301 |
3 |
G |
A |
14 |
48 |
homozygous |
73: |
143451986 |
143451987 |
3 |
C |
T |
9 |
28 |
homozygous |
74: |
143451868 |
143451869 |
3 |
G |
A |
15 |
42 |
homozygous |
75: |
143451840 |
143451841 |
3 |
T |
C |
15 |
51 |
homozygous |
76: |
143451816 |
143451817 |
3 |
T |
C |
19 |
58 |
homozygous |
77: |
143451773 |
143451774 |
3 |
G |
A |
20 |
63 |
homozygous |
78: |
143451074 |
143451075 |
3 |
G |
A |
12 |
40 |
homozygous |
79: |
143451016 |
143451017 |
3 |
T |
G |
12 |
40 |
homozygous |
80: |
143450738 |
143450739 |
3 |
C |
T |
23 |
76 |
homozygous |
81: |
143449132 |
143449133 |
3 |
T |
C |
20 |
64 |
homozygous |
82: |
143448566 |
143448567 |
3 |
G |
T |
19 |
59 |
homozygous |
83: |
143447892 |
143447893 |
3 |
C |
T |
11 |
34 |
possibly homozygous |
84: |
143447883 |
143447884 |
3 |
A |
G |
9 |
29 |
homozygous |
SHR Sequence Variants
1: |
143488515 |
143488516 |
3 |
T |
A |
2: |
143488485 |
143488486 |
3 |
C |
G |
3: |
143486899 |
143486900 |
3 |
G |
A |
4: |
143485051 |
143485052 |
3 |
C |
T |
5: |
143484513 |
143484514 |
3 |
A |
G |
6: |
143484142 |
143484143 |
3 |
T |
C |
7: |
143483996 |
143483997 |
3 |
G |
A |
|
NM_013185 |
synonymous |
K |
K |
F |
Not Available |
|
|
8: |
143482235 |
143482236 |
3 |
T |
C |
9: |
143481463 |
143481464 |
3 |
A |
G |
10: |
143480633 |
143480634 |
3 |
G |
C |
11: |
143480301 |
143480302 |
3 |
G |
A |
12: |
143480131 |
143480132 |
3 |
G |
A |
13: |
143479565 |
143479566 |
3 |
G |
A |
14: |
143479564 |
143479565 |
3 |
T |
C |
15: |
143479523 |
143479524 |
3 |
A |
T |
16: |
143479493 |
143479494 |
3 |
A |
G |
17: |
143478684 |
143478685 |
3 |
G |
A |
18: |
143478385 |
143478386 |
3 |
A |
G |
19: |
143478370 |
143478371 |
3 |
G |
A |
20: |
143478022 |
143478023 |
3 |
T |
C |
21: |
143477980 |
143477981 |
3 |
C |
T |
22: |
143477885 |
143477886 |
3 |
T |
C |
23: |
143477846 |
143477847 |
3 |
G |
A |
24: |
143477252 |
143477253 |
3 |
G |
A |
25: |
143476632 |
143476633 |
3 |
C |
T |
|
NM_013185 |
synonymous |
A |
A |
F |
Not Available |
|
|
26: |
143475936 |
143475937 |
3 |
G |
T |
27: |
143475887 |
143475888 |
3 |
C |
A |
28: |
143475846 |
143475847 |
3 |
G |
A |
29: |
143474922 |
143474923 |
3 |
C |
T |
30: |
143474869 |
143474870 |
3 |
G |
A |
31: |
143474219 |
143474220 |
3 |
A |
G |
32: |
143474100 |
143474101 |
3 |
T |
C |
33: |
143473754 |
143473755 |
3 |
C |
A |
34: |
143473705 |
143473706 |
3 |
C |
T |
35: |
143473254 |
143473255 |
3 |
T |
C |
36: |
143473068 |
143473069 |
3 |
A |
G |
37: |
143472968 |
143472969 |
3 |
C |
T |
38: |
143472884 |
143472885 |
3 |
G |
C |
39: |
143472828 |
143472829 |
3 |
A |
G |
40: |
143472257 |
143472258 |
3 |
T |
C |
41: |
143472185 |
143472186 |
3 |
T |
C |
42: |
143471809 |
143471810 |
3 |
T |
C |
43: |
143471599 |
143471600 |
3 |
C |
T |
44: |
143471160 |
143471161 |
3 |
G |
A |
45: |
143471122 |
143471123 |
3 |
C |
T |
46: |
143470889 |
143470890 |
3 |
A |
T |
47: |
143470845 |
143470846 |
3 |
A |
T |
48: |
143470664 |
143470665 |
3 |
A |
C |
49: |
143470279 |
143470280 |
3 |
G |
A |
50: |
143469952 |
143469953 |
3 |
A |
G |
51: |
143469877 |
143469878 |
3 |
G |
A |
52: |
143469431 |
143469432 |
3 |
A |
G |
|
NM_013185 |
synonymous |
V |
V |
F |
Not Available |
|
|
53: |
143469331 |
143469332 |
3 |
A |
C |
54: |
143469248 |
143469249 |
3 |
T |
C |
55: |
143469027 |
143469028 |
3 |
C |
T |
56: |
143467505 |
143467506 |
3 |
C |
T |
57: |
143466342 |
143466343 |
3 |
C |
T |
58: |
143463103 |
143463104 |
3 |
C |
T |
59: |
143461280 |
143461281 |
3 |
A |
G |
60: |
143461063 |
143461064 |
3 |
G |
A |
61: |
143460585 |
143460586 |
3 |
G |
A |
62: |
143459428 |
143459429 |
3 |
G |
A |
63: |
143459416 |
143459417 |
3 |
A |
G |
64: |
143459236 |
143459237 |
3 |
T |
C |
65: |
143458713 |
143458714 |
3 |
C |
T |
66: |
143458544 |
143458545 |
3 |
T |
C |
67: |
143455790 |
143455791 |
3 |
A |
G |
68: |
143454386 |
143454387 |
3 |
G |
A |
69: |
143454060 |
143454061 |
3 |
C |
A |
70: |
143453701 |
143453702 |
3 |
G |
A |
71: |
143453468 |
143453469 |
3 |
T |
C |
72: |
143451887 |
143451888 |
3 |
C |
T |
73: |
143451096 |
143451097 |
3 |
G |
T |
74: |
143450940 |
143450941 |
3 |
C |
T |
75: |
143450738 |
143450739 |
3 |
C |
T |
76: |
143450655 |
143450656 |
3 |
G |
A |
77: |
143450412 |
143450413 |
3 |
C |
A |
78: |
143449983 |
143449984 |
3 |
A |
G |
79: |
143449656 |
143449657 |
3 |
C |
T |
80: |
143449192 |
143449193 |
3 |
C |
T |
81: |
143449132 |
143449133 |
3 |
T |
C |
82: |
143448912 |
143448913 |
3 |
T |
A |
83: |
143448749 |
143448750 |
3 |
T |
C |
84: |
143448177 |
143448178 |
3 |
A |
G |
85: |
143447883 |
143447884 |
3 |
A |
G |
SS Sequence Variants
1: |
143490036 |
143490037 |
3 |
A |
C |
20 |
67 |
homozygous |
2: |
143488822 |
143488823 |
3 |
T |
A |
5 |
15 |
homozygous |
3: |
143488515 |
143488516 |
3 |
T |
A |
7 |
21 |
homozygous |
4: |
143488485 |
143488486 |
3 |
C |
G |
15 |
49 |
homozygous |
5: |
143486820 |
143486821 |
3 |
A |
T |
21 |
69 |
homozygous |
6: |
143486629 |
143486630 |
3 |
G |
A |
8 |
8 |
heterozygous |
7: |
143486244 |
143486245 |
3 |
G |
A |
4 |
14 |
homozygous |
8: |
143486076 |
143486077 |
3 |
A |
G |
16 |
53 |
homozygous |
9: |
143486033 |
143486034 |
3 |
G |
A |
13 |
39 |
homozygous |
10: |
143485800 |
143485801 |
3 |
G |
A |
24 |
64 |
homozygous |
11: |
143484866 |
143484867 |
3 |
C |
T |
27 |
90 |
homozygous |
12: |
143484724 |
143484725 |
3 |
C |
A |
20 |
68 |
homozygous |
13: |
143484513 |
143484514 |
3 |
A |
G |
25 |
78 |
homozygous |
14: |
143484142 |
143484143 |
3 |
T |
C |
16 |
52 |
homozygous |
15: |
143483875 |
143483876 |
3 |
G |
A |
19 |
60 |
homozygous |
16: |
143483806 |
143483807 |
3 |
A |
G |
4 |
12 |
homozygous |
17: |
143483696 |
143483697 |
3 |
C |
G |
9 |
29 |
homozygous |
18: |
143482996 |
143482997 |
3 |
C |
T |
26 |
85 |
homozygous |
19: |
143482857 |
143482858 |
3 |
C |
T |
23 |
80 |
homozygous |
20: |
143482756 |
143482757 |
3 |
G |
A |
20 |
63 |
homozygous |
21: |
143482681 |
143482682 |
3 |
G |
A |
21 |
67 |
homozygous |
22: |
143482495 |
143482496 |
3 |
A |
G |
13 |
46 |
homozygous |
23: |
143482330 |
143482331 |
3 |
C |
G |
28 |
89 |
homozygous |
24: |
143482235 |
143482236 |
3 |
T |
C |
28 |
87 |
possibly homozygous |
25: |
143481463 |
143481464 |
3 |
A |
G |
18 |
58 |
homozygous |
26: |
143481286 |
143481287 |
3 |
G |
A |
14 |
48 |
homozygous |
27: |
143481255 |
143481256 |
3 |
C |
G |
13 |
44 |
homozygous |
28: |
143481095 |
143481096 |
3 |
C |
T |
14 |
49 |
homozygous |
29: |
143480633 |
143480634 |
3 |
G |
C |
17 |
54 |
homozygous |
30: |
143480301 |
143480302 |
3 |
G |
A |
16 |
50 |
homozygous |
31: |
143479842 |
143479843 |
3 |
G |
A |
13 |
44 |
homozygous |
32: |
143479493 |
143479494 |
3 |
A |
G |
14 |
48 |
homozygous |
33: |
143477980 |
143477981 |
3 |
C |
T |
18 |
60 |
homozygous |
34: |
143477252 |
143477253 |
3 |
G |
A |
34 |
110 |
homozygous |
35: |
143476325 |
143476326 |
3 |
G |
A |
39 |
125 |
homozygous |
36: |
143476204 |
143476205 |
3 |
T |
A |
27 |
87 |
homozygous |
37: |
143475846 |
143475847 |
3 |
G |
A |
19 |
60 |
homozygous |
38: |
143474904 |
143474905 |
3 |
A |
G |
21 |
68 |
homozygous |
39: |
143474359 |
143474360 |
3 |
G |
A |
20 |
63 |
homozygous |
40: |
143474100 |
143474101 |
3 |
T |
C |
23 |
71 |
possibly homozygous |
41: |
143473396 |
143473397 |
3 |
T |
C |
6 |
21 |
homozygous |
42: |
143473391 |
143473392 |
3 |
C |
T |
8 |
14 |
heterozygous |
43: |
143473385 |
143473386 |
3 |
C |
T |
9 |
8 |
heterozygous |
44: |
143473068 |
143473069 |
3 |
A |
G |
11 |
36 |
homozygous |
45: |
143472976 |
143472977 |
3 |
C |
T |
17 |
56 |
homozygous |
46: |
143471575 |
143471576 |
3 |
G |
T |
23 |
78 |
homozygous |
47: |
143471188 |
143471189 |
3 |
G |
T |
27 |
91 |
homozygous |
48: |
143470845 |
143470846 |
3 |
A |
T |
17 |
57 |
homozygous |
49: |
143470349 |
143470350 |
3 |
G |
A |
22 |
59 |
homozygous |
50: |
143469952 |
143469953 |
3 |
A |
G |
14 |
42 |
homozygous |
51: |
143469877 |
143469878 |
3 |
G |
A |
6 |
21 |
homozygous |
52: |
143469796 |
143469797 |
3 |
A |
T |
6 |
21 |
homozygous |
53: |
143469751 |
143469752 |
3 |
G |
T |
9 |
21 |
heterozygous |
54: |
143469248 |
143469249 |
3 |
T |
C |
10 |
33 |
homozygous |
55: |
143468807 |
143468808 |
3 |
C |
A |
26 |
87 |
homozygous |
56: |
143467598 |
143467599 |
3 |
G |
A |
24 |
69 |
homozygous |
57: |
143467505 |
143467506 |
3 |
C |
T |
26 |
90 |
homozygous |
58: |
143466167 |
143466168 |
3 |
A |
G |
15 |
52 |
homozygous |
59: |
143465693 |
143465694 |
3 |
A |
G |
10 |
23 |
homozygous |
60: |
143464979 |
143464980 |
3 |
A |
G |
5 |
18 |
homozygous |
61: |
143464865 |
143464866 |
3 |
C |
A |
15 |
52 |
homozygous |
62: |
143462641 |
143462642 |
3 |
G |
A |
24 |
83 |
homozygous |
63: |
143462218 |
143462219 |
3 |
G |
T |
9 |
8 |
heterozygous |
64: |
143462140 |
143462141 |
3 |
A |
G |
11 |
32 |
homozygous |
65: |
143461979 |
143461980 |
3 |
C |
T |
25 |
79 |
homozygous |
66: |
143459236 |
143459237 |
3 |
T |
C |
3 |
11 |
homozygous |
67: |
143459010 |
143459011 |
3 |
C |
T |
13 |
44 |
homozygous |
68: |
143458713 |
143458714 |
3 |
C |
T |
22 |
78 |
homozygous |
69: |
143458064 |
143458065 |
3 |
G |
A |
21 |
71 |
homozygous |
70: |
143455794 |
143455795 |
3 |
C |
T |
13 |
45 |
homozygous |
71: |
143455790 |
143455791 |
3 |
A |
G |
14 |
48 |
homozygous |
72: |
143455219 |
143455220 |
3 |
C |
T |
18 |
53 |
homozygous |
73: |
143453942 |
143453943 |
3 |
G |
A |
24 |
80 |
homozygous |
74: |
143452777 |
143452778 |
3 |
G |
A |
21 |
57 |
homozygous |
75: |
143452509 |
143452510 |
3 |
C |
T |
33 |
107 |
homozygous |
76: |
143452300 |
143452301 |
3 |
G |
A |
15 |
52 |
homozygous |
77: |
143451986 |
143451987 |
3 |
C |
T |
24 |
76 |
homozygous |
78: |
143451868 |
143451869 |
3 |
G |
A |
11 |
32 |
homozygous |
79: |
143451840 |
143451841 |
3 |
T |
C |
19 |
62 |
homozygous |
80: |
143451816 |
143451817 |
3 |
T |
C |
24 |
74 |
homozygous |
81: |
143451773 |
143451774 |
3 |
G |
A |
28 |
94 |
homozygous |
82: |
143451074 |
143451075 |
3 |
G |
A |
14 |
44 |
possibly homozygous |
83: |
143451016 |
143451017 |
3 |
T |
G |
13 |
44 |
homozygous |
84: |
143450738 |
143450739 |
3 |
C |
T |
25 |
82 |
homozygous |
85: |
143449132 |
143449133 |
3 |
T |
C |
25 |
81 |
homozygous |
86: |
143448566 |
143448567 |
3 |
G |
T |
31 |
105 |
homozygous |
87: |
143447892 |
143447893 |
3 |
C |
T |
9 |
25 |
homozygous |
88: |
143447883 |
143447884 |
3 |
A |
G |
11 |
39 |
homozygous |
Additional Information
External Database Links
Nomenclature History
Date |
Current Symbol |
Current Name |
Previous Symbol |
Previous Name |
Description |
Reference |
Status |
2002-06-10 |
Hck |
Hemopoietic cell tyrosine kinase |
|
|
Symbol and Name status set to approved |
1490 |
APPROVED |
RGD Curation Notes
Note Type |
Note |
Reference |
gene_protein |
503 amino acids |
728421 |
gene_transcript |
1911 nucleotides |
728421 |
gene_product |
member of the src family of tyrosine kinases |
1298942
|
gene_expression |
expressed predominantly myeloid and B-lymphoid lineage cells |
1298942
|
No hay comentarios:
Publicar un comentario