Gene: Hck (hemopoietic cell kinase) Rattus norvegicus

Symbol:	Hck
Name:	hemopoietic cell kinase
Description:	ENCODES a protein that exhibits protein tyrosine kinase activity (ortholog); INVOLVED IN defense response to Gram-positive bacterium (ortholog); negative regulation of apoptotic process (ortholog); peptidyl-tyrosine phosphorylation (ortholog); PARTICIPATES IN Interleukin-6 signaling pathway; eicosanoids signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; FOUND IN actin filament (ortholog); caveola (ortholog); extrinsic to internal side of plasma membrane (ortholog); INTERACTS WITH 2,6-di-tert-butyl-4-methylphenol; ammonium chloride; cefaloridine
Type:	protein-coding
RefSeq Status:	VALIDATED
Also known as:	HCTK; hemopoietic cell tyrosine kinase; Hctk; hemopoietic cell kinase; p56-HCK; tyrosine-protein kinase HCK; p56Hck; p59Hck; hematopoietic cell kinase
Orthologs:	Homo sapiens : HCK (hemopoietic cell kinase) Mus musculus : Hck (hemopoietic cell kinase)
Latest Assembly:	RGSC Genome Assembly v3.4
Position:	Map Chr Position Strand Source Rat Cytogenetic Map 3 q41 NCBI Rat Rnor_5.0 3 154,982,909 - 155,025,529 + NCBI RGSC Genome Assembly v3.4 3 143,447,697 - 143,490,281 + NCBI Rat Celera Assembly 3 140,318,662 - 140,361,702 + NCBI Genome Assembly 3.1 3 143,353,318 - 143,395,900 + NCBI RH 3.4 3 1263.9 RGD
Model	Launch Genome Browser (GBrowse)

Annotation (Toggle Detail/Summary View)

Gene-Chemical Interaction Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:732472	6480464	Tetrachlorodibenzodioxin results in increased expression of HCK mRNA	CTD	PMID:21041162
2,6-di-tert-butyl-4-methylphenol	affects expression	EXP		6480464	Butylated Hydroxytoluene affects the expression of HCK mRNA	CTD	PMID:18539377
4-hydroxynon-2-enal	decreases expression	ISO	RGD:732472	6480464	4-hydroxy-2-nonenal results in decreased expression of HCK mRNA	CTD	PMID:19191707
5-aza-2'-deoxycytidine	multiple interactions	ISO	RGD:732471	6480464	[decitabine affects the methylation of HCK promoter] which affects the expression of HCK mRNA	CTD	PMID:17344919
5-aza-2'-deoxycytidine	multiple interactions	ISO	RGD:732471	6480464	[decitabine affects the methylation of HCK promoter] which affects the expression of HCK mRNA	CTD	PMID:17344919 PMID:17344919
5-aza-2'-deoxycytidine	increases expression	ISO	RGD:732471	6480464	decitabine results in increased expression of HCK protein	CTD	PMID:17344919
5-aza-2'-deoxycytidine	affects methylation	ISO	RGD:732471	6480464	decitabine affects the methylation of HCK promoter	CTD	PMID:17344919
acetylsalicylic acid	decreases expression	ISO	RGD:732471	6480464	Aspirin results in decreased expression of HCK mRNA	CTD	PMID:15928584
all-trans-retinoic acid	increases expression	ISO	RGD:732471	6480464	Tretinoin results in increased expression of HCK mRNA	CTD	PMID:15498508 PMID:16054129
all-trans-retinoic acid	increases expression	ISO	RGD:732471	6480464	Tretinoin results in increased expression of HCK mRNA	CTD	PMID:16054129 PMID:15498508
all-trans-retinoic acid	decreases expression	ISO	RGD:732472	6480464	Tretinoin results in decreased expression of HCK mRNA	CTD	PMID:16604517
all-trans-retinoic acid	increases expression	ISO	RGD:732471	6480464	Tretinoin results in increased expression of HCK mRNA	CTD	PMID:16054129
ammonium chloride	affects expression	EXP		6480464	Ammonium Chloride affects the expression of HCK mRNA	CTD	PMID:16483693
bathocuproine disulfonic acid	multiple interactions	ISO	RGD:732471	6480464	[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HCK mRNA]	CTD	PMID:15477007
cadmium dichloride	multiple interactions	ISO	RGD:732471	6480464	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of HCK mRNA	CTD	PMID:12634122
cefaloridine	increases expression	EXP		6480464	Cephaloridine results in increased expression of HCK mRNA	CTD	PMID:18500788
dasatinib	decreases phosphorylation	ISO	RGD:732471	6480464	dasatinib results in decreased phosphorylation of HCK protein	CTD	PMID:18180381
dexamethasone	increases expression	ISO	RGD:732472	6480464	Dexamethasone results in increased expression of HCK mRNA	CTD	PMID:21041162
dibutyl phthalate	decreases expression	ISO	RGD:732472	6480464	Dibutyl Phthalate results in decreased expression of HCK mRNA	CTD	PMID:21266533
dichromium trioxide	multiple interactions	ISO	RGD:732471	6480464	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of HCK mRNA	CTD	PMID:12634122
diethylstilbestrol	increases expression	ISO	RGD:732472	6480464	Diethylstilbestrol results in increased expression of HCK mRNA	CTD	PMID:21041162
ionomycin	multiple interactions	ISO	RGD:732471	6480464	[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HCK mRNA]	CTD	PMID:15477007
lead diacetate	multiple interactions	ISO	RGD:732471	6480464	[sodium arsenite co-treated with Cadmium Chloride co-treated with chromium oxide co-treated with chromous chloride co-treated with lead acetate] results in decreased expression of HCK mRNA	CTD	PMID:12634122
methotrexate	affects expression	ISO	RGD:732472	6480464	Methotrexate affects the expression of HCK mRNA	CTD	PMID:18502557
ozone	decreases expression	EXP		6480464	Ozone results in decreased expression of HCK mRNA	CTD	PMID:16330353
paracetamol	affects expression	ISO	RGD:732472	6480464	Acetaminophen affects the expression of HCK mRNA	CTD	PMID:17562736
phorbol 13-acetate 12-myristate	multiple interactions	ISO	RGD:732471	6480464	[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HCK mRNA]	CTD	PMID:15477007
pirinixic acid	decreases expression	ISO	RGD:732472	6480464	pirinixic acid results in decreased expression of HCK mRNA	CTD	PMID:17426115
tamibarotene	increases expression	ISO	RGD:732471	6480464	Am 80 results in increased expression of HCK mRNA	CTD	PMID:15498508
testosterone enanthate	affects expression	ISO	RGD:732471	6480464	testosterone enanthate affects the expression of HCK mRNA	CTD	PMID:17440010
triphenylstannane	increases expression	ISO	RGD:732471	6480464	triphenyltin results in increased expression of HCK protein	CTD	PMID:12788061

Gene Ontology Annotations

Biological Process

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
defense response to Gram-positive bacterium		IEA	Ensembl:ENSMUSP00000003370	1600115	GO_REF:0000019	ENSEMBL	GO_REF:0000019
defense response to Gram-positive bacterium		ISO	RGD:732472	1624291	MGI:MGI:95527	RGD	MGI:MGI:65050 PMID:8125254
exocytosis		IEA	UniProtKB-KW:KW-0268	1600115	GO_REF:0000037	UniProtKB	GO_REF:0000037
inflammatory response		IEA	UniProtKB-KW:KW-0395	1600115	GO_REF:0000037	UniProtKB	GO_REF:0000037
innate immune response		IEA	UniProtKB-KW:KW-0399	1600115	GO_REF:0000037	UniProtKB	GO_REF:0000037
negative regulation of apoptotic process		ISO	RGD:732471	1624291	PMID:17535448	RGD	PMID:17535448
negative regulation of apoptotic process		IEA	Ensembl:ENSP00000365012	1600115	GO_REF:0000019	ENSEMBL	GO_REF:0000019
peptidyl-tyrosine phosphorylation		ISO	RGD:732471	1624291	PMID:10092522	RGD	PMID:10092522
peptidyl-tyrosine phosphorylation		ISS	UniProtKB:P08631	1600115	GO_REF:0000024	UniProtKB	GO_REF:0000024
peptidyl-tyrosine phosphorylation		IEA	Ensembl:ENSP00000365012	1600115	GO_REF:0000019	ENSEMBL	GO_REF:0000019
phagocytosis		IEA	Ensembl:ENSMUSP00000003370	1600115	GO_REF:0000019	ENSEMBL	GO_REF:0000019
phagocytosis		ISO	RGD:732472	1624291	MGI:MGI:2384049	RGD	MGI:MGI:65050 PMID:8125254
positive regulation of actin cytoskeleton reorganization		ISO	RGD:732471	1624291	PMID:11904303	RGD	PMID:11904303
positive regulation of actin cytoskeleton reorganization		ISS	UniProtKB:P08631	1600115	GO_REF:0000024	UniProtKB	GO_REF:0000024
positive regulation of actin cytoskeleton reorganization		IEA	Ensembl:ENSP00000365012	1600115	GO_REF:0000019	ENSEMBL	GO_REF:0000019
positive regulation of actin cytoskeleton reorganization		ISO	RGD:732471	1624291	PMID:15998323	RGD	PMID:15998323
positive regulation of cell proliferation		ISO	RGD:732471	1624291	PMID:10092522	RGD	PMID:10092522
positive regulation of cell proliferation		ISS	UniProtKB:P08631	1600115	GO_REF:0000024	UniProtKB	GO_REF:0000024
positive regulation of cell proliferation		IEA	Ensembl:ENSP00000365012	1600115	GO_REF:0000019	ENSEMBL	GO_REF:0000019
protein autophosphorylation		ISO	RGD:732471	1624291	PMID:10092522	RGD	PMID:10092522
protein autophosphorylation		ISS	UniProtKB:P08631	1600115	GO_REF:0000024	UniProtKB	GO_REF:0000024
protein autophosphorylation		IEA	Ensembl:ENSP00000365012	1600115	GO_REF:0000019	ENSEMBL	GO_REF:0000019
regulation of cell shape		ISO	RGD:732471	1624291	PMID:10092522	RGD	PMID:10092522
regulation of cell shape		ISS	UniProtKB:P08631	1600115	GO_REF:0000024	UniProtKB	GO_REF:0000024
regulation of cell shape		IEA	Ensembl:ENSP00000365012	1600115	GO_REF:0000019	ENSEMBL	GO_REF:0000019
regulation of cell shape		ISO	RGD:732471	1624291	PMID:11904303	RGD	PMID:11904303
regulation of phagocytosis		ISO	RGD:732471	1624291	PMID:11904303	RGD	PMID:11904303
regulation of phagocytosis		ISS	UniProtKB:P08631	1600115	GO_REF:0000024	UniProtKB	GO_REF:0000024
regulation of phagocytosis		IEA	Ensembl:ENSP00000365012	1600115	GO_REF:0000019	ENSEMBL	GO_REF:0000019
regulation of podosome assembly		ISO	RGD:732471	1624291	PMID:15998323	RGD	PMID:15998323
regulation of podosome assembly		ISS	UniProtKB:P08631	1600115	GO_REF:0000024	UniProtKB	GO_REF:0000024
regulation of podosome assembly		IEA	Ensembl:ENSP00000365012	1600115	GO_REF:0000019	ENSEMBL	GO_REF:0000019
regulation of sequence-specific DNA binding transcription factor activity		ISO	RGD:732471	1624291	PMID:17535448	RGD	PMID:17535448
regulation of sequence-specific DNA binding transcription factor activity		IEA	Ensembl:ENSP00000365012	1600115	GO_REF:0000019	ENSEMBL	GO_REF:0000019

Cellular Component

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Golgi apparatus		IEA	UniProtKB-SubCell:SL-0132	1600115	GO_REF:0000039	UniProtKB	GO_REF:0000039
actin filament	colocalizes_with	ISO	RGD:732471	1624291	PMID:15998323	RGD	PMID:15998323
actin filament		ISS	UniProtKB:P08631	1600115	GO_REF:0000024	UniProtKB	GO_REF:0000024
actin filament		IEA	Ensembl:ENSP00000365012	1600115	GO_REF:0000019	ENSEMBL	GO_REF:0000019
caveola		ISO	RGD:732471	1624291	PMID:7791757	RGD	PMID:7791757
caveola		IEA	UniProtKB-SubCell:SL-0035	1600115	GO_REF:0000039	UniProtKB	GO_REF:0000039
caveola		IEA	Ensembl:ENSP00000365012	1600115	GO_REF:0000019	ENSEMBL	GO_REF:0000019
cell projection		IEA	UniProtKB-KW:KW-0966	1600115	GO_REF:0000037	UniProtKB	GO_REF:0000037
cytosol		IEA	UniProtKB-SubCell:SL-0091	1600115	GO_REF:0000039	UniProtKB	GO_REF:0000039
extrinsic to internal side of plasma membrane		ISO	RGD:732471	1624291	PMID:11904303	RGD	PMID:11904303
extrinsic to internal side of plasma membrane		ISS	UniProtKB:P08631	1600115	GO_REF:0000024	UniProtKB	GO_REF:0000024
extrinsic to internal side of plasma membrane		IEA	Ensembl:ENSP00000365012	1600115	GO_REF:0000019	ENSEMBL	GO_REF:0000019
focal adhesion		ISO	RGD:732471	1624291	PMID:11904303	RGD	PMID:11904303
focal adhesion		IEA	UniProtKB-SubCell:SL-0118	1600115	GO_REF:0000039	UniProtKB	GO_REF:0000039
focal adhesion		IEA	Ensembl:ENSP00000365012	1600115	GO_REF:0000019	ENSEMBL	GO_REF:0000019
lysosome		ISO	RGD:732471	1624291	PMID:15998323	RGD	PMID:15998323
lysosome		ISS	UniProtKB:P08631	1600115	GO_REF:0000024	UniProtKB	GO_REF:0000024
lysosome		IEA	Ensembl:ENSP00000365012	1600115	GO_REF:0000019	ENSEMBL	GO_REF:0000019
nucleus		IEA	UniProtKB-SubCell:SL-0191	1600115	GO_REF:0000039	UniProtKB	GO_REF:0000039
transport vesicle		IEA	UniProtKB-SubCell:SL-0244	1600115	GO_REF:0000039	UniProtKB	GO_REF:0000039

Molecular Function

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
ATP binding		IEA	UniProtKB-KW:KW-0067	1600115	GO_REF:0000038	UniProtKB	GO_REF:0000038
non-membrane spanning protein tyrosine kinase activity		IEA	EC:2.7.10.2	1600115	GO_REF:0000003	UniProtKB	GO_REF:0000003
protein binding		ISO	RGD:732471	1624291	UniProtKB:P12504	RGD	PMID:11278465
protein binding		ISO	RGD:732471	1624291	UniProtKB:P03406	RGD	PMID:7859737
protein binding		ISO	RGD:732471	1624291	UniProtKB:O92972	RGD	PMID:15784897
protein binding		ISO	RGD:732471	1624291	UniProtKB:O92972	RGD	PMID:14993658
protein binding		ISO	RGD:732471	1624291	UniProtKB:O43516	RGD	PMID:12029088
protein tyrosine kinase activity		ISO	RGD:732471	1624291	PMID:10092522	RGD	PMID:10092522
protein tyrosine kinase activity		ISS	UniProtKB:P08631	1600115	GO_REF:0000024	UniProtKB	GO_REF:0000024
protein tyrosine kinase activity		IEA	Ensembl:ENSP00000365012	1600115	GO_REF:0000019	ENSEMBL	GO_REF:0000019

Molecular Pathway Annotations

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Interleukin-6 signaling pathway		ISO	RGD:732471	6484113		PID	PID:200146
eicosanoids signaling pathway		ISO	RGD:732471	6484113		PID	PID:200082
ephrin - ephrin receptor bidirectional signaling axis		ISO	RGD:732471	6484113		PID	PID:200204
ephrin - ephrin receptor bidirectional signaling axis		ISO	RGD:732471	6484113		PID	PID:200142
glypican signaling pathway		ISO	RGD:732471	6484113		PID	PID:200026
phosphatidylinositol 3-kinase class I signaling pathway		ISO	RGD:732471	6484113		PID	PID:200116
platelet-derived growth factor signaling pathway		ISO	RGD:732471	6484113		PID	PID:200149

External Database Links
KEGG Pathway	04062
	04666
Pathway Interaction Database	Alpha-synuclein signaling (PID:200219)
	amb2 Integrin signaling (PID:200127)
	Class I PI3K signaling events (PID:200116)
	CXCR4-mediated signaling events (PID:200099)
	EPHA forward signaling (PID:200142)
	Ephrin B reverse signaling (PID:200204)
	Glypican 1 network (PID:200026)
	IL6-mediated signaling events (PID:200146)
	IL8- and CXCR1-mediated signaling events (PID:200199)
	IL8- and CXCR2-mediated signaling events (PID:200167)
	PDGFR-beta signaling pathway (PID:200149)
	Regulation of p38-alpha and p38-beta (PID:200066)
	Signaling events mediated by PTP1B (PID:200042)
	Thromboxane A2 receptor signaling (PID:200082)

Gene-Chemical Interaction Annotations

2,3,7,8-tetrachlorodibenzodioxine (ISO) 2,6-di-tert-butyl-4-methylphenol (EXP) 4-hydroxynon-2-enal (ISO) 5-aza-2'-deoxycytidine (ISO) acetylsalicylic acid (ISO) all-trans-retinoic acid (ISO) ammonium chloride (EXP) bathocuproine disulfonic acid (ISO) cadmium dichloride (ISO)

cefaloridine (EXP) dasatinib (ISO) dexamethasone (ISO) dibutyl phthalate (ISO) dichromium trioxide (ISO) diethylstilbestrol (ISO) ionomycin (ISO) lead diacetate (ISO) methotrexate (ISO)

ozone (EXP) paracetamol (ISO) phorbol 13-acetate 12-myristate (ISO) pirinixic acid (ISO) tamibarotene (ISO) testosterone enanthate (ISO) triphenylstannane (ISO)

Gene Ontology Annotations

Biological Process

defense response to Gram-positive bacterium (IEA,ISO) exocytosis (IEA) inflammatory response (IEA) innate immune response (IEA) negative regulation of apoptotic process (IEA,ISO) peptidyl-tyrosine phosphorylation (IEA,ISO,ISS) phagocytosis (IEA,ISO) positive regulation of actin cytoskeleton reorganization (IEA,ISO,ISS)

positive regulation of cell proliferation (IEA,ISO,ISS) protein autophosphorylation (IEA,ISO,ISS) regulation of cell shape (IEA,ISO,ISS) regulation of phagocytosis (IEA,ISO,ISS) regulation of podosome assembly (IEA,ISO,ISS) regulation of sequence-specific DNA binding transcription factor activity (IEA,ISO)

Cellular Component

actin filament (IEA,ISO,ISS) caveola (IEA,ISO) cell projection (IEA) cytosol (IEA)

extrinsic to internal side of plasma membrane (IEA,ISO,ISS) focal adhesion (IEA,ISO) Golgi apparatus (IEA) lysosome (IEA,ISO,ISS)

nucleus (IEA) transport vesicle (IEA)

Molecular Function

ATP binding (IEA) non-membrane spanning protein tyrosine kinase activity (IEA)

protein binding (ISO) protein tyrosine kinase activity (IEA,ISO,ISS)

Molecular Pathway Annotations

eicosanoids signaling pathway (ISO) ephrin - ephrin receptor bidirectional signaling axis (ISO) glypican signaling pathway (ISO) Interleukin-6 signaling pathway (ISO)

phosphatidylinositol 3-kinase class I signaling pathway (ISO) platelet-derived growth factor signaling pathway (ISO)

External Database Links
KEGG Pathway	04062
	04666
Pathway Interaction Database	Alpha-synuclein signaling (PID:200219)
	amb2 Integrin signaling (PID:200127)
	Class I PI3K signaling events (PID:200116)
	CXCR4-mediated signaling events (PID:200099)
	EPHA forward signaling (PID:200142)
	Ephrin B reverse signaling (PID:200204)
	Glypican 1 network (PID:200026)
	IL6-mediated signaling events (PID:200146)
	IL8- and CXCR1-mediated signaling events (PID:200199)
	IL8- and CXCR2-mediated signaling events (PID:200167)
	PDGFR-beta signaling pathway (PID:200149)
	Regulation of p38-alpha and p38-beta (PID:200066)
	Signaling events mediated by PTP1B (PID:200042)
	Thromboxane A2 receptor signaling (PID:200082)

References - curated

1.	Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
2.	GOA data from the GO Consortium
3.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
4.	Lock P, etal., Mol Cell Biol 1991 Sep;11(9):4363-70.
5.	MGD data from the GO Consortium
6.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	Okano Y, etal., Biochem Biophys Res Commun 1991 Dec 31;181(3):1137-44.
8.	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9.	RGD automated import pipeline for gene-chemical interactions
10.	Strausberg RL, etal., Proc Natl Acad Sci U S A 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11.	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

References - uncurated

PubMed	14551197
	15489334

RGD Disease Portals

Hck has been annotated in the following RGD Disease Portals.
	Biological Process Cancer Pathways
	Cardiovascular Pathways
	Diabetes Pathways
	Biological Process Immune and Inflammatory Pathways
	Neurological Pathways
	Obesity Pathways
	Biological Process Respiratory Pathways

Genomics

Comparative Map Data

Hck (Rattus norvegicus)	Map Chr Position Strand Source Rat Cytogenetic Map 3 q41 NCBI Rat Rnor_5.0 3 154,982,909 - 155,025,529 + NCBI RGSC Genome Assembly v3.4 3 143,447,697 - 143,490,281 + NCBI Rat Celera Assembly 3 140,318,662 - 140,361,702 + NCBI Genome Assembly 3.1 3 143,353,318 - 143,395,900 + NCBI RH 3.4 3 1263.9 RGD
HCK (Homo sapiens)	Map Chr Position Strand Source Human Genome Assembly HuRef 20 27,428,653 - 27,478,333 + NCBI Human Genome Assembly GRCh37 20 30,639,991 - 30,689,659 + NCBI Human Genome Assembly Build 36 20 30,103,718 - 30,153,320 + NCBI Human Cytogenetic Map 20 q11-q12 NCBI Human Genome Assembly 20 30,103,717 - 30,153,316 NCBI
Hck (Mus musculus)	Map Chr Position Strand Source Mouse Genome Assembly GRCm38 2 153,108,468 - 153,151,441 + NCBI Mouse cM Map 2 86.0 NCBI Mouse Celera Assembly 2 158,934,831 - 158,977,872 + NCBI Mouse Genome Assembly Build 37 2 152,934,204 - 152,977,177 + NCBI Mouse Genome Assembly Build 36.1 2 152,934,244 - 152,977,172 + NCBI Mouse Cytogenetic Map 2 H1 NCBI

Position Markers

J03023	Map Chr Position Strand Source RGSC Genome Assembly v3.4 3 143,490,054 - 143,490,208 UniSTS Rat Celera Assembly 3 140,361,475 - 140,361,629 UniSTS
RH94532	Map Chr Position Strand Source RGSC Genome Assembly v3.4 3 143,490,039 - 143,490,208 UniSTS Rat Celera Assembly 3 140,361,460 - 140,361,629 UniSTS RH 3.4 3 1263.9 UniSTS
RH137385	Map Chr Position Strand Source RGSC Genome Assembly v3.4 3 143,490,089 - 143,490,244 UniSTS Rat Celera Assembly 3 140,361,510 - 140,361,665 UniSTS RH 3.4 3 1275.0 UniSTS
UniSTS:498385	Map Chr Position Strand Source RGSC Genome Assembly v3.4 3 143,489,822 - 143,490,224 UniSTS Rat Celera Assembly 3 140,361,243 - 140,361,645 UniSTS

QTLs in Region (RGSC Genome Assembly v3.4)

The following QTLs overlap with this region.

Full Report

CSV

TAB

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RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
619618	Rf3	Renal disease susceptibility QTL 3	6.5	.001	Renal function	urine albumin level	3	108688653	153688653	Rat
631541	Bp81	Blood pressure QTL 81	4		Blood pressure	systolic	3	124893448	171063335	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		Glucose level	post-pancreatectomy	3	93894678	161985069	Rat
631665	Bw8	Body weight QTL 8	5.5		Body weight		3	47722501	171063335	Rat
631673	Iddm13	Insulin dependent diabetes mellitus QTL 13	1.1	.014	Insulin level		3	131188558	163778754	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		Mammary tumor susceptibility	estradiol-induced	3	41054012	171063335	Rat
1300159	Kidm4	Kidney mass QTL 4	3.83		Kidney mass	hypertension related	3	121618954	159769019	Rat
1300161	Rf10	Renal function QTL 10	3.57		Renal function	hypertension related renal vascular resistance	3	101298208	163335184	Rat
1300173	Rf11	Renal function QTL 11	3.38		Renal function	hypertension related renal blood flow	3	121618954	147990731	Rat
1576306	Schws3	Schwannoma susceptibility QTL 3		.001	Neural tumor susceptibility	tumor incidence	3	120714678	165714678	Rat
1581568	Rf53	Renal function QTL 53			Renal function	urine protein level	3	53876762	163443738	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		Vascular neointimal growth after injury	blood vessel neointimal area	3	132947812	171063335	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		Vascular neointimal growth after injury	blood vessel lumen size	3	132947812	171063335	Rat
1578754	Stresp16	Stress response QTL 16	4	.001	Stress response	plasma renin activity	3	113902006	158902006	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	.0335	Renal function	urine protein level	3	76620970	148642985	Rat
2301970	Bw81	Body weight QTL 81	5.19		Body weight		3	39052756	158038027	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			Gland mass	thymus	3	44551252	149496698	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.37		Glucose level	insulin-dependent	3	96506745	149496698	Rat
1598877	Bp285	Blood pressure QTL 285	1.5	.03	Blood pressure	systolic	3	122541511	167541511	Rat
2312670	Bw94	Body weight QTL 94		.01	Body weight	adiposity index	3	97523869	170016653	Rat
2312673	Scl63	Serum cholesterol level QTL 63		.001	Lipid level	serum cholesterol	3	97523869	170016653	Rat
2312659	Slep7	Serum leptin concentration QTL 7		.001	Hormone level	leptin	3	97523869	170016653	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		Glucose level		3	97524000	163778606	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.1		Ventilatory control	hypoxic challenge	3	127988419	170016653	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		.0011	Uvea inflammation		3	139485124	171063335	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		Cardiac mass	left ventricle	3	39052756	158038027	Rat
5686842	Rf59	Renal function QTL 59			Renal function	urine protein level	3	141890119	149038578	Rat

Sequence

Nucleotide Sequences

Nucleotide RefSeqs	NM_013185	(Get FASTA)	Search GEO for Microarray Profiles
GenBank Nucleotide	BC078890	(Get FASTA)	Search GEO for Microarray Profiles
	BU760053	(Get FASTA)	Search GEO for Microarray Profiles
	CH474050	(Get FASTA)	Search GEO for Microarray Profiles
	M83666	(Get FASTA)	Search GEO for Microarray Profiles
	S74141	(Get FASTA)	Search GEO for Microarray Profiles
	X62345	(Get FASTA)	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:	NM_013185
RefSeq Status:	VALIDATED
Type:	CODING
Protein Acc Id:	NP_037317
Position:	Map Chr Position Strand Source Rat Rnor_5.0 3 154,982,909 - 155,025,529 + NCBI RGSC Genome Assembly v3.4 3 143,447,697 - 143,490,281 + RGD Rat Celera Assembly 3 140,318,662 - 140,361,702 + NCBI

Protein Sequences

Protein RefSeqs	NP_037317	(Get FASTA)
GenBank Protein	AAA41312	(Get FASTA)
	AAB20754	(Get FASTA)
	AAH78890	(Get FASTA)
	CAA44218	(Get FASTA)
	EDL86018	(Get FASTA)
	P50545	(Get FASTA)

Strain Variation

FHH Sequence Variants

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Variant	Start	Stop	Chr	Reference Nucleotide	Variant Nucleotide	Depth	Allele Frequency	Zygosity
1:	143490036	143490037	3	A	C	16	56	homozygous
2:	143488515	143488516	3	T	A	15	46	homozygous
3:	143488485	143488486	3	C	G	16	53	homozygous
4:	143486820	143486821	3	A	T	13	37	homozygous
5:	143486076	143486077	3	A	G	9	30	homozygous
6:	143486033	143486034	3	G	A	13	44	homozygous
7:	143485800	143485801	3	G	A	25	76	homozygous
8:	143484866	143484867	3	C	T	13	45	homozygous
9:	143484724	143484725	3	C	A	18	62	homozygous
10:	143484513	143484514	3	A	G	22	76	homozygous
11:	143484445	143484446	3	A	C	7	7	heterozygous
12:	143484444	143484445	3	C	A	6	16	homozygous
13:	143484142	143484143	3	T	C	19	61	homozygous
14:	143483875	143483876	3	G	A	17	54	homozygous
15:	143483696	143483697	3	C	G	11	38	homozygous
16:	143482996	143482997	3	C	T	19	58	possibly homozygous
17:	143482857	143482858	3	C	T	21	67	homozygous
18:	143482756	143482757	3	G	A	20	60	homozygous
19:	143482681	143482682	3	G	A	16	56	homozygous
20:	143482495	143482496	3	A	G	29	85	homozygous
21:	143482330	143482331	3	C	G	25	84	homozygous
22:	143482235	143482236	3	T	C	26	83	homozygous
23:	143481463	143481464	3	A	G	7	23	homozygous
24:	143481286	143481287	3	G	A	11	33	possibly homozygous
25:	143481255	143481256	3	C	G	15	45	homozygous
26:	143481095	143481096	3	C	T	14	47	homozygous
27:	143480633	143480634	3	G	C	22	61	homozygous
28:	143480301	143480302	3	G	A	17	54	homozygous
29:	143479842	143479843	3	G	A	15	44	homozygous
30:	143479493	143479494	3	A	G	16	50	homozygous
31:	143477980	143477981	3	C	T	23	71	homozygous
32:	143477252	143477253	3	G	A	11	37	homozygous
33:	143476325	143476326	3	G	A	20	67	homozygous
34:	143476204	143476205	3	T	A	15	40	homozygous
35:	143475846	143475847	3	G	A	17	57	homozygous
36:	143474904	143474905	3	A	G	16	53	homozygous
37:	143474359	143474360	3	G	A	21	66	homozygous
38:	143474100	143474101	3	T	C	21	63	homozygous
39:	143473396	143473397	3	T	C	7	20	possibly homozygous
40:	143473068	143473069	3	A	G	8	25	homozygous
41:	143472976	143472977	3	C	T	13	39	homozygous
42:	143471575	143471576	3	G	T	21	74	homozygous
43:	143471188	143471189	3	G	T	16	51	homozygous
44:	143470845	143470846	3	A	T	14	44	homozygous
45:	143470349	143470350	3	G	A	13	35	possibly homozygous
46:	143469952	143469953	3	A	G	25	74	homozygous
47:	143469877	143469878	3	G	A	13	42	possibly homozygous
48:	143469248	143469249	3	T	C	19	62	homozygous
49:	143468807	143468808	3	C	A	13	45	homozygous
50:	143467598	143467599	3	G	A	25	70	possibly homozygous
51:	143467505	143467506	3	C	T	29	99	homozygous
52:	143466167	143466168	3	A	G	14	44	homozygous
53:	143465693	143465694	3	A	G	7	16	homozygous
54:	143465329	143465330	3	C	A	7	7	heterozygous
55:	143464979	143464980	3	A	G	11	28	possibly homozygous
56:	143464865	143464866	3	C	A	18	60	homozygous
57:	143462641	143462642	3	G	A	23	71	homozygous
58:	143462140	143462141	3	A	G	13	35	homozygous
59:	143461979	143461980	3	C	T	19	60	homozygous
60:	143459264	143459265	3	G	A	3	11	homozygous
61:	143459236	143459237	3	T	C	4	12	homozygous
62:	143459010	143459011	3	C	T	7	18	homozygous
63:	143458713	143458714	3	C	T	17	55	homozygous
64:	143458064	143458065	3	G	A	15	51	homozygous
65:	143457562	143457563	3	C	G	6	20	homozygous
66:	143455794	143455795	3	C	T	15	48	homozygous
67:	143455790	143455791	3	A	G	16	55	homozygous
68:	143455219	143455220	3	C	T	12	35	homozygous
69:	143453942	143453943	3	G	A	26	84	homozygous
70:	143452777	143452778	3	G	A	16	51	homozygous
71:	143452509	143452510	3	C	T	19	60	homozygous
72:	143452300	143452301	3	G	A	14	48	homozygous
73:	143451986	143451987	3	C	T	9	28	homozygous
74:	143451868	143451869	3	G	A	15	42	homozygous
75:	143451840	143451841	3	T	C	15	51	homozygous
76:	143451816	143451817	3	T	C	19	58	homozygous
77:	143451773	143451774	3	G	A	20	63	homozygous
78:	143451074	143451075	3	G	A	12	40	homozygous
79:	143451016	143451017	3	T	G	12	40	homozygous
80:	143450738	143450739	3	C	T	23	76	homozygous
81:	143449132	143449133	3	T	C	20	64	homozygous
82:	143448566	143448567	3	G	T	19	59	homozygous
83:	143447892	143447893	3	C	T	11	34	possibly homozygous
84:	143447883	143447884	3	A	G	9	29	homozygous

SHR Sequence Variants

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Variant	Start	Stop	Chr	Reference Nucleotide	Variant Nucleotide
1:	143488515	143488516	3	T	A
2:	143488485	143488486	3	C	G
3:	143486899	143486900	3	G	A
4:	143485051	143485052	3	C	T
5:	143484513	143484514	3	A	G
6:	143484142	143484143	3	T	C
7:	143483996	143483997	3	G	A
	Amino Acid Change Transcript Type Reference AA Variant AA Near Splice Site Polyphen Prediction NM_013185 synonymous K K F Not Available
8:	143482235	143482236	3	T	C
9:	143481463	143481464	3	A	G
10:	143480633	143480634	3	G	C
11:	143480301	143480302	3	G	A
12:	143480131	143480132	3	G	A
13:	143479565	143479566	3	G	A
14:	143479564	143479565	3	T	C
15:	143479523	143479524	3	A	T
16:	143479493	143479494	3	A	G
17:	143478684	143478685	3	G	A
18:	143478385	143478386	3	A	G
19:	143478370	143478371	3	G	A
20:	143478022	143478023	3	T	C
21:	143477980	143477981	3	C	T
22:	143477885	143477886	3	T	C
23:	143477846	143477847	3	G	A
24:	143477252	143477253	3	G	A
25:	143476632	143476633	3	C	T
	Amino Acid Change Transcript Type Reference AA Variant AA Near Splice Site Polyphen Prediction NM_013185 synonymous A A F Not Available
26:	143475936	143475937	3	G	T
27:	143475887	143475888	3	C	A
28:	143475846	143475847	3	G	A
29:	143474922	143474923	3	C	T
30:	143474869	143474870	3	G	A
31:	143474219	143474220	3	A	G
32:	143474100	143474101	3	T	C
33:	143473754	143473755	3	C	A
34:	143473705	143473706	3	C	T
35:	143473254	143473255	3	T	C
36:	143473068	143473069	3	A	G
37:	143472968	143472969	3	C	T
38:	143472884	143472885	3	G	C
39:	143472828	143472829	3	A	G
40:	143472257	143472258	3	T	C
41:	143472185	143472186	3	T	C
42:	143471809	143471810	3	T	C
43:	143471599	143471600	3	C	T
44:	143471160	143471161	3	G	A
45:	143471122	143471123	3	C	T
46:	143470889	143470890	3	A	T
47:	143470845	143470846	3	A	T
48:	143470664	143470665	3	A	C
49:	143470279	143470280	3	G	A
50:	143469952	143469953	3	A	G
51:	143469877	143469878	3	G	A
52:	143469431	143469432	3	A	G
	Amino Acid Change Transcript Type Reference AA Variant AA Near Splice Site Polyphen Prediction NM_013185 synonymous V V F Not Available
53:	143469331	143469332	3	A	C
54:	143469248	143469249	3	T	C
55:	143469027	143469028	3	C	T
56:	143467505	143467506	3	C	T
57:	143466342	143466343	3	C	T
58:	143463103	143463104	3	C	T
59:	143461280	143461281	3	A	G
60:	143461063	143461064	3	G	A
61:	143460585	143460586	3	G	A
62:	143459428	143459429	3	G	A
63:	143459416	143459417	3	A	G
64:	143459236	143459237	3	T	C
65:	143458713	143458714	3	C	T
66:	143458544	143458545	3	T	C
67:	143455790	143455791	3	A	G
68:	143454386	143454387	3	G	A
69:	143454060	143454061	3	C	A
70:	143453701	143453702	3	G	A
71:	143453468	143453469	3	T	C
72:	143451887	143451888	3	C	T
73:	143451096	143451097	3	G	T
74:	143450940	143450941	3	C	T
75:	143450738	143450739	3	C	T
76:	143450655	143450656	3	G	A
77:	143450412	143450413	3	C	A
78:	143449983	143449984	3	A	G
79:	143449656	143449657	3	C	T
80:	143449192	143449193	3	C	T
81:	143449132	143449133	3	T	C
82:	143448912	143448913	3	T	A
83:	143448749	143448750	3	T	C
84:	143448177	143448178	3	A	G
85:	143447883	143447884	3	A	G

SS Sequence Variants

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Variant	Start	Stop	Chr	Reference Nucleotide	Variant Nucleotide	Depth	Allele Frequency	Zygosity
1:	143490036	143490037	3	A	C	20	67	homozygous
2:	143488822	143488823	3	T	A	5	15	homozygous
3:	143488515	143488516	3	T	A	7	21	homozygous
4:	143488485	143488486	3	C	G	15	49	homozygous
5:	143486820	143486821	3	A	T	21	69	homozygous
6:	143486629	143486630	3	G	A	8	8	heterozygous
7:	143486244	143486245	3	G	A	4	14	homozygous
8:	143486076	143486077	3	A	G	16	53	homozygous
9:	143486033	143486034	3	G	A	13	39	homozygous
10:	143485800	143485801	3	G	A	24	64	homozygous
11:	143484866	143484867	3	C	T	27	90	homozygous
12:	143484724	143484725	3	C	A	20	68	homozygous
13:	143484513	143484514	3	A	G	25	78	homozygous
14:	143484142	143484143	3	T	C	16	52	homozygous
15:	143483875	143483876	3	G	A	19	60	homozygous
16:	143483806	143483807	3	A	G	4	12	homozygous
17:	143483696	143483697	3	C	G	9	29	homozygous
18:	143482996	143482997	3	C	T	26	85	homozygous
19:	143482857	143482858	3	C	T	23	80	homozygous
20:	143482756	143482757	3	G	A	20	63	homozygous
21:	143482681	143482682	3	G	A	21	67	homozygous
22:	143482495	143482496	3	A	G	13	46	homozygous
23:	143482330	143482331	3	C	G	28	89	homozygous
24:	143482235	143482236	3	T	C	28	87	possibly homozygous
25:	143481463	143481464	3	A	G	18	58	homozygous
26:	143481286	143481287	3	G	A	14	48	homozygous
27:	143481255	143481256	3	C	G	13	44	homozygous
28:	143481095	143481096	3	C	T	14	49	homozygous
29:	143480633	143480634	3	G	C	17	54	homozygous
30:	143480301	143480302	3	G	A	16	50	homozygous
31:	143479842	143479843	3	G	A	13	44	homozygous
32:	143479493	143479494	3	A	G	14	48	homozygous
33:	143477980	143477981	3	C	T	18	60	homozygous
34:	143477252	143477253	3	G	A	34	110	homozygous
35:	143476325	143476326	3	G	A	39	125	homozygous
36:	143476204	143476205	3	T	A	27	87	homozygous
37:	143475846	143475847	3	G	A	19	60	homozygous
38:	143474904	143474905	3	A	G	21	68	homozygous
39:	143474359	143474360	3	G	A	20	63	homozygous
40:	143474100	143474101	3	T	C	23	71	possibly homozygous
41:	143473396	143473397	3	T	C	6	21	homozygous
42:	143473391	143473392	3	C	T	8	14	heterozygous
43:	143473385	143473386	3	C	T	9	8	heterozygous
44:	143473068	143473069	3	A	G	11	36	homozygous
45:	143472976	143472977	3	C	T	17	56	homozygous
46:	143471575	143471576	3	G	T	23	78	homozygous
47:	143471188	143471189	3	G	T	27	91	homozygous
48:	143470845	143470846	3	A	T	17	57	homozygous
49:	143470349	143470350	3	G	A	22	59	homozygous
50:	143469952	143469953	3	A	G	14	42	homozygous
51:	143469877	143469878	3	G	A	6	21	homozygous
52:	143469796	143469797	3	A	T	6	21	homozygous
53:	143469751	143469752	3	G	T	9	21	heterozygous
54:	143469248	143469249	3	T	C	10	33	homozygous
55:	143468807	143468808	3	C	A	26	87	homozygous
56:	143467598	143467599	3	G	A	24	69	homozygous
57:	143467505	143467506	3	C	T	26	90	homozygous
58:	143466167	143466168	3	A	G	15	52	homozygous
59:	143465693	143465694	3	A	G	10	23	homozygous
60:	143464979	143464980	3	A	G	5	18	homozygous
61:	143464865	143464866	3	C	A	15	52	homozygous
62:	143462641	143462642	3	G	A	24	83	homozygous
63:	143462218	143462219	3	G	T	9	8	heterozygous
64:	143462140	143462141	3	A	G	11	32	homozygous
65:	143461979	143461980	3	C	T	25	79	homozygous
66:	143459236	143459237	3	T	C	3	11	homozygous
67:	143459010	143459011	3	C	T	13	44	homozygous
68:	143458713	143458714	3	C	T	22	78	homozygous
69:	143458064	143458065	3	G	A	21	71	homozygous
70:	143455794	143455795	3	C	T	13	45	homozygous
71:	143455790	143455791	3	A	G	14	48	homozygous
72:	143455219	143455220	3	C	T	18	53	homozygous
73:	143453942	143453943	3	G	A	24	80	homozygous
74:	143452777	143452778	3	G	A	21	57	homozygous
75:	143452509	143452510	3	C	T	33	107	homozygous
76:	143452300	143452301	3	G	A	15	52	homozygous
77:	143451986	143451987	3	C	T	24	76	homozygous
78:	143451868	143451869	3	G	A	11	32	homozygous
79:	143451840	143451841	3	T	C	19	62	homozygous
80:	143451816	143451817	3	T	C	24	74	homozygous
81:	143451773	143451774	3	G	A	28	94	homozygous
82:	143451074	143451075	3	G	A	14	44	possibly homozygous
83:	143451016	143451017	3	T	G	13	44	homozygous
84:	143450738	143450739	3	C	T	25	82	homozygous
85:	143449132	143449133	3	T	C	25	81	homozygous
86:	143448566	143448567	3	G	T	31	105	homozygous
87:	143447892	143447893	3	C	T	9	25	homozygous
88:	143447883	143447884	3	A	G	11	39	homozygous

Additional Information

External Database Links

Ensembl Genes	ENSRNOG00000009331
	ENSRNOG00000009331
Ensembl Protein	ENSRNOP00000012432
	ENSRNOP00000012432
Ensembl Transcript	ENSRNOT00000012432
	ENSRNOT00000012432
Entrez Gene	25734
Gene3D-CATH	SH2
Germonline	ENSRNOG00000009331
HomoloGene Group ID	20489
IMAGE_CLONE	IMAGE:7121407
InterPro	Prot_kinase_cat_dom
	SH2
	Ser-Thr/Tyr-Pkinase
	SH3_domain
	Tyr_prot_kinase_AS
	Kinase-like_dom
	Protein_kinase_ATP_BS
	Tyr_Pkinase_cat_dom
IPI	IPI00325226
	IPI00817068
KEGG Report	rno:25734
	rno:25734
MGC_CLONE	MGC:93602
Pfam	SH2
	SH3_1
	Pkinase_Tyr
PRINTS	TYRKINASE
	SH2DOMAIN
	SH3DOMAIN
PROSITE	PROTEIN_KINASE_ATP
	PROTEIN_KINASE_TYR
	SH2
	SH3
	PROTEIN_KINASE_DOM
SMART	TyrKc
	SH2
	SH3
Superfamily-SCOP	SH3
	Kinase_like
TIGR	TC222854
UniGene	Rn.10945
UniProt	F1LP43_RAT
	HCK_RAT

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Hck	Hemopoietic cell tyrosine kinase			Symbol and Name status set to approved	1490	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_protein	503 amino acids	728421
gene_transcript	1911 nucleotides	728421
gene_product	member of the src family of tyrosine kinases	1298942
gene_expression	expressed predominantly myeloid and B-lymphoid lineage cells	1298942